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NH2-PEG-phenol-PEG-COOtBu

PROTAC Linker

NH2-PEG-phenol-PEG-COOtBu is a PEG-based PROTAC linker designed to enhance the coupling efficiency for targeted protein degradation. Its primary mechanism involves facilitating the synthesis of PROTACs, enabling them to recruit E3 ligases for ubiquitination of target proteins. This compound serves as a valuable tool in the development of PROTACs, including applications in cancer research and the study of protein degradation pathways.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2417370-72-8
Applications	PROTAC Linker
Formula	C₁₆H₂₅NO₅
Molecular Weight	311.37
SMILES	O=C(COCCC1=CC(OCCN)=CC(O)=C1)OC(C)(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.