Fig. 1 · Structure
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NHE-1-IN-2
NHE-1 Inhibitor
NHE-1-IN-2 is a potent inhibitor of the sodium-hydrogen exchanger 1 (NHE-1), exhibiting an IC50 of 0.78 μM. This compound has demonstrated efficacy in alleviating left ventricular systolic dysfunction in a mouse model of heart failure, making it an important tool for research into cardiovascular conditions and potential therapeutic interventions. Its ability to modulate NHE-1 activity highlights its significance in studying cardiac pathophysiology and pharmacological responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3107091-05-1 |
| Applications | NHE-1 Inhibitor |
| Formula | C23H20ClN3O3 |
| Molecular Weight | 421.88 |
| SMILES | O=C(C1=CC=C(C2=CC=C(Cl)C(C(C3=CC=C(OCC)C=C3)=O)=C2)C=C1)NC(N)=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.