Fig. 1 · Structure
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NIAD-4
Amyloid-β Fluorophore
NIAD-4 is a blood-brain barrier permeable fluorophore specifically designed for optical imaging of amyloid-β (Aβ) in the central nervous system, particularly relevant for Alzheimer's disease research. This compound exhibits a high binding affinity to Aβ with a Ki of 10 nM, enabling precise visualization of Aβ aggregates in various experimental models. Its application is crucial for studying the pathophysiology of Alzheimer's disease and assessing the efficacy of therapeutic interventions targeting Aβ accumulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 868592-56-7 |
| Applications | Amyloid-β Fluorophore |
| Formula | C18H10N2OS2 |
| Molecular Weight | 334.43 |
| SMILES | N#C/C(C#N)=C/C1=CC=C(C2=CC=C(C3=CC=C(O)C=C3)S2)S1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.