Fig. 1 · Structure
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Ninerafaxstat trihydrochloride
Mitotropic Agent
Ninerafaxstat trihydrochloride is a mitotropic agent that functions as a competitive inhibitor of 3-ketoacyl-CoA thiolase (3-KAT). By partially suppressing fatty acid oxidation, it promotes a shift from free fatty acid oxidation to glucose oxidation in cardiac tissues, thus enhancing myocardial energy homeostasis and improving cardiac efficiency. This compound is particularly relevant for research applications focused on cardiovascular diseases and myocardial substrate utilization.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2311824-72-1 |
| Applications | Mitotropic Agent |
| Formula | C22H32Cl3N3O5 |
| Molecular Weight | 524.87 |
| Synonyms | MB-1018972 trihydrochloride; IMB-101 trihydrochloride |
| SMILES | O=C(C1=CC=CN=C1)OCCN2CCN(CC3=CC=C(OC)C(OC)=C3OC)CC2.[H]Cl.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.