Fig. 1 · Structure
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Ninerafaxstat
Mitotropic Agent
Ninerafaxstat (IMB-1018972) is an innovative mitotropic agent that targets 3-ketoacyl-CoA thiolase (3-KAT), leading to a competitive inhibition that partially suppresses fatty acid oxidation. This mechanism shifts cardiac energy metabolism from free fatty acids to glucose oxidation, thereby enhancing myocardial substrate utilization and improving cardiac efficiency. Ninerafaxstat is a valuable tool for research in cardiovascular diseases, contributing to the understanding of cardiac energy homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2254741-41-6 |
| Applications | Mitotropic Agent |
| Formula | C22H29N3O5 |
| Molecular Weight | 415.48 |
| Synonyms | IMB-1018972; IMB-101 |
| SMILES | O=C(C1=CC=CN=C1)OCCN2CCN(CC2)CC3=CC=C(C(OC)=C3OC)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.