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Biological Activity
NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.31 mL | 91.56 mL | 183.12 mL |
| 0.5 mM | 3.66 mL | 18.31 mL | 36.62 mL |
| 1 mM | 1.83 mL | 9.16 mL | 18.31 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
*The above data is based on the productmolecular weight 546.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19567 |
|---|---|
| CAS No. | 138605-00-2 |
| Formula | C27H44ClNO8 |
| M. Wt | 546.09 |
| Purity | >98% |
| Synonyms | Colforsin dapropate hydrochloride, NKH-477, NKH 477 |
| SMILES | O[[email protected]@]12[[email protected]@]3([[email protected]@](C(C)(CC[[email protected]@H]3O)C)([H])[[email protected]](OC(CCN(C)C)=O)[[email protected]](OC(C)=O)[[email protected]]1(O[[email protected]](C=C)(C)CC2=O)C)C.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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