Fig. 1 · Structure
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NLRP3-IN-11
NLRP3 Proteins Inhibitor
NLRP3-IN-11 is a potent inhibitor of NLR family pyrin domain containing 3 (NLRP3) proteins, exhibiting an IC50 value of less than 0.3 μM. It demonstrates significant biological activity in modulating NLRP3 signaling, making it a valuable tool for research into inflammatory and degenerative diseases. Applications include the study of non-alcoholic steatohepatitis (NASH), atherosclerosis, Alzheimer's disease, Parkinson's disease, diabetes, gout, and various autoinflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2769040-91-5 |
| Applications | NLRP3 Proteins Inhibitor |
| Formula | C17H17ClN4O2 |
| Molecular Weight | 344.80 |
| SMILES | ClC1=CC=C(C2=C3C=CN=CC3=C(NCC(C)(C)O)N=N2)C(O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.