Fig. 1 · Structure
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NLRP3-IN-15
NLRP3 Inhibitor
NLRP3-IN-15 is a selective inhibitor of the NLRP3 inflammasome, targeting the pathway responsible for the activation of pro-inflammatory cytokines. With an IC50 of 0.114 μM, NLRP3-IN-15 effectively inhibits the release of IL-1β, a key mediator in inflammatory responses. This compound is suitable for investigating the role of NLRP3 in various inflammatory disorders and related research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2767369-71-9 |
| Applications | NLRP3 Inhibitor |
| Formula | C22H19NO4 |
| Molecular Weight | 361.39 |
| SMILES | CC1=C2C=CC3=C(C2=CC=C1)C(C(C4=C3OC5=C4CCN(C5)CCO)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.