Fig. 1 · Structure
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NLRP3-IN-17
NLRP3 Inflammasome Inhibitor
NLRP3-IN-17 is a selective and orally bioactive inhibitor of the NLRP3 inflammasome, exhibiting an IC50 value of 7 nM. This compound effectively inhibits NLRP3-dependent secretion of IL-1β in murine models, making it a valuable tool for investigating the mechanisms underlying chronic inflammatory diseases. NLRP3-IN-17 is suited for research applications focused on the modulation of immune responses and the development of therapeutic strategies targeting inflammatory pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2254432-75-0 |
| Applications | NLRP3 Inflammasome Inhibitor |
| Formula | C21H22N4O2S |
| Molecular Weight | 394.49 |
| SMILES | N#CN=S(NC(NC1=C(CCC2)C2=CC3=C1CCC3)=O)(C4=CC=C(C)C=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.