Fig. 1 · Structure
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NLRP3-IN-20
NLRP3 Inhibitor
NLRP3-IN-20 is a potent inhibitor of the NLRP3 inflammasome, exhibiting an IC50 value of 25 nM for the secretion of IL-1β. This compound possesses strong pharmacokinetic properties, making it suitable for in vivo studies. NLRP3-IN-20 has shown significant efficacy in various research models, including non-alcoholic steatohepatitis, fatal septic shock, and colitis, thereby serving as a valuable tool for investigating inflammation-related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2428478-22-0 |
| Applications | NLRP3 Inhibitor |
| Formula | C22H27N3O3S |
| Molecular Weight | 413.53 |
| SMILES | O=S(C1=CC=C(CN(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.