Fig. 1 · Structure
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NLRP3-IN-21
NLRP3 Inhibitor
NLRP3-IN-21 is a selective NLRP3 inflammasome inhibitor that effectively mitigates inflammatory processes. This compound disrupts NLRP3 inflammasome activation and inhibits pyroptosis by preventing gasdermin D cleavage, ASC oligomerization, and the assembly of the inflammasome complex. NLRP3-IN-21 is valuable for research applications focused on understanding inflammatory diseases and developing potential therapeutic strategies targeting the NLRP3 pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2956791-61-8 |
| Applications | NLRP3 Inhibitor |
| Formula | C20H13Cl2F3N6O2S |
| Molecular Weight | 529.32 |
| SMILES | O=C1N(N=C(N2C1=CC3=C2C=C(S3)Cl)C(C)C)CC4=NN=C(O4)C5=CC=C(N=C5Cl)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.