NLRP3-IN-21

Catalog No.: A35566
NLRP3 Inhibitor
NLRP3-IN-21 is a selective NLRP3 inflammasome inhibitor that effectively mitigates inflammatory processes. This compound disrupts NLRP3 inflammasome activation and inhibits pyroptosis by preventing gasdermin D cleavage, ASC oligomerization, and the assembly of the inflammasome complex. NLRP3-IN-21 is valuable for research applications focused on understanding inflammatory diseases and developing potential therapeutic strategies targeting the NLRP3 pathway.
Grouped product items
Size Price Stock Qty
5mg
$310.00
In stock
10mg
$510.00
In stock
25mg
$1,075.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNLRP3-IN-21 is a selective NLRP3 inflammasome inhibitor that effectively mitigates inflammatory processes. This compound disrupts NLRP3 inflammasome activation and inhibits pyroptosis by preventing gasdermin D cleavage, ASC oligomerization, and the assembly of the inflammasome complex. NLRP3-IN-21 is valuable for research applications focused on understanding inflammatory diseases and developing potential therapeutic strategies targeting the NLRP3 pathway.
Product Information
Catalog NumA35566
FormulaC20H13Cl2F3N6O2S
Molecular Weight529.32
CAS Number2956791-61-8
SMILESO=C1N(N=C(N2C1=CC3=C2C=C(S3)Cl)C(C)C)CC4=NN=C(O4)C5=CC=C(N=C5Cl)C(F)(F)F
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