NLRP3-IN-25 is an orally available NLRP3 inhibitor that exhibits significant anti-inflammatory properties. It effectively reduces renal injury in a doxorubicin-induced glomerulonephritis model in mice. Additionally, NLRP3-IN-25 demonstrates the ability to inhibit IL-1β secretion in THP-1 cells, with an IC50 value of 21 nM, making it a valuable tool for research into NLRP3-related inflammatory conditions.
NLRP3-IN-25 is an orally available NLRP3 inhibitor that exhibits significant anti-inflammatory properties. It effectively reduces renal injury in a doxorubicin-induced glomerulonephritis model in mice. Additionally, NLRP3-IN-25 demonstrates the ability to inhibit IL-1β secretion in THP-1 cells, with an IC50 value of 21 nM, making it a valuable tool for research into NLRP3-related inflammatory conditions.
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