Fig. 1 · Structure
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NLRP3-IN-25
NLRP3 Inhibitor
NLRP3-IN-25 is an orally available NLRP3 inhibitor that exhibits significant anti-inflammatory properties. It effectively reduces renal injury in a doxorubicin-induced glomerulonephritis model in mice. Additionally, NLRP3-IN-25 demonstrates the ability to inhibit IL-1β secretion in THP-1 cells, with an IC50 value of 21 nM, making it a valuable tool for research into NLRP3-related inflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2660230-90-8 |
| Applications | NLRP3 Inhibitor |
| Formula | C17H19F3N4O5S |
| Molecular Weight | 448.42 |
| SMILES | O=C(C1=COC(NC2=CC(C(F)(F)F)=CC=C2C)=N1)NS(=O)(N3CCOCCC3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.