NLRP3-IN-34 is a potent inhibitor of the NLRP3 inflammasome, targeting its activation and downstream signaling. It effectively inhibits reactive oxygen species (ROS) production and interleukin-1 beta (IL-1β) release, exhibiting an IC50 of 0.48 μM in J774A.1 cells. Additionally, NLRP3-IN-34 has demonstrated the capability to inhibit pyroptosis and exhibits anti-inflammatory effects, particularly in models of dextran sulfate sodium (DSS)-induced peritonitis. This compound is valuable for research focused on inflammation and related disease mechanisms.
NLRP3-IN-34 is a potent inhibitor of the NLRP3 inflammasome, targeting its activation and downstream signaling. It effectively inhibits reactive oxygen species (ROS) production and interleukin-1 beta (IL-1β) release, exhibiting an IC50 of 0.48 μM in J774A.1 cells. Additionally, NLRP3-IN-34 has demonstrated the capability to inhibit pyroptosis and exhibits anti-inflammatory effects, particularly in models of dextran sulfate sodium (DSS)-induced peritonitis. This compound is valuable for research focused on inflammation and related disease mechanisms.
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