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NLRP3-IN-44

NLRP3 Inhibitor

NLRP3-IN-44 is a selective inhibitor of the NLRP3 inflammasome, exhibiting potent activity with a Kd of 17.5 nM and approximately 62% oral bioavailability. This compound facilitates research into NLRP3-related pathologies by effectively modulating inflammasome activity. NLRP3-IN-44 is valuable for investigations into the roles of the NLRP3 inflammasome in inflammatory diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3040298-34-5
Applications	NLRP3 Inhibitor
Formula	C₂₅H₃₀N₄O₃
Molecular Weight	434.53
SMILES	OC1=C(C(N=NC(N[C@H]2CN(CCC2)CCO)=C34)=C3C5CCC4CC5)C=CC6=C1C=CO6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.