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NLRP3-IN-61

NLRP3 Inhibitor

NLRP3-IN-61 is a potent inhibitor of NLRP3, targeting the NLRP3 inflammasome pathway. This compound effectively inhibits pyroptosis in THP-1 cells with an IC50 value of 12.6 nM and reduces IL-1β release with an IC50 of 25.3 nM. NLRP3-IN-61 is suitable for research applications investigating inflammatory responses and therapeutic interventions in diseases associated with the NLRP3 inflammasome.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3060585-94-3
Applications	NLRP3 Inhibitor
Formula	C₂₁H₂₁N₃O₃
Molecular Weight	363.41
SMILES	OC1=C(CCC2)C2=CC(C)=C1C3=CC=C(OC([C@@H]4CCC(NC4)=O)=N5)C5=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.