Documents & Downloads

NLRP3-IN-62

NLRP3 Inhibitor

NLRP3-IN-62 is a selective inhibitor of the NLRP3 inflammasome, demonstrated to effectively inhibit pyroptosis in THP-1 cells with an IC50 of 0.7 nM. Additionally, it suppresses the release of interleukin-1 beta (IL-1β) with an IC50 of 108.5 nM. This compound serves as a valuable tool for research in inflammation and immune responses, particularly in studies related to diseases involving pyroptotic cell death.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3059965-71-5
Applications	NLRP3 Inhibitor
Formula	C₂₁H₁₅F₃N₄O₃
Molecular Weight	428.36
SMILES	O=C1C=C2C(CN(C2)C3=NC4=NC(C5=C(C=C(C(F)(F)F)C=C5C)O)=CC=C4O3)=CN1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.