NLRP3-IN-77 is a potent inhibitor of the NLRP3 inflammasome, demonstrating an IC50 value of 5.36 nM in suppressing the viability of THP-1 cells. This compound effectively reduces the secretion of pro-inflammatory cytokines, specifically interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3-IN-77 is a valuable tool for investigating diseases associated with aberrant NLRP3 inflammasome activation, including various cancers and inflammatory disorders.
NLRP3-IN-77 is a potent inhibitor of the NLRP3 inflammasome, demonstrating an IC50 value of 5.36 nM in suppressing the viability of THP-1 cells. This compound effectively reduces the secretion of pro-inflammatory cytokines, specifically interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3-IN-77 is a valuable tool for investigating diseases associated with aberrant NLRP3 inflammasome activation, including various cancers and inflammatory disorders.
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