NLRP3-IN-8 is a potent inhibitor of the NLRP3 inflammasome, acting through direct binding with an IC50 of 1.23 μM against IL-1β. This compound demonstrates notable metabolic stability, with a half-life of 138.63 minutes in liver microsomes, and exhibits minimal toxicity, as indicated by an IC50 greater than 100 μM against L02 cells. NLRP3-IN-8 is valuable for research into inflammatory disorders and potential therapeutic interventions targeting the NLRP3 pathway.
NLRP3-IN-8 is a potent inhibitor of the NLRP3 inflammasome, acting through direct binding with an IC50 of 1.23 μM against IL-1β. This compound demonstrates notable metabolic stability, with a half-life of 138.63 minutes in liver microsomes, and exhibits minimal toxicity, as indicated by an IC50 greater than 100 μM against L02 cells. NLRP3-IN-8 is valuable for research into inflammatory disorders and potential therapeutic interventions targeting the NLRP3 pathway.
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