NLRP3-IN-86 is a selective inhibitor of the NLRP3 inflammasome. This compound demonstrates significant potency in reducing lipopolysaccharide (LPS) and Nigericin-induced lactate dehydrogenase release, with IC50 values of 2.69 μM in THP-1 cells and 1.75 μM in J774A.1 cells. Additionally, NLRP3-IN-86 effectively inhibits gasdermin D cleavage and interleukin-1 beta (IL-1β) secretion, thereby mitigating pyroptosis. This reagent is ideally suited for investigations into inflammatory processes and the underlying mechanisms of pyroptotic cell death.
NLRP3-IN-86 is a selective inhibitor of the NLRP3 inflammasome. This compound demonstrates significant potency in reducing lipopolysaccharide (LPS) and Nigericin-induced lactate dehydrogenase release, with IC50 values of 2.69 μM in THP-1 cells and 1.75 μM in J774A.1 cells. Additionally, NLRP3-IN-86 effectively inhibits gasdermin D cleavage and interleukin-1 beta (IL-1β) secretion, thereby mitigating pyroptosis. This reagent is ideally suited for investigations into inflammatory processes and the underlying mechanisms of pyroptotic cell death.
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