NLRP3-IN-NBC6 is a selective inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 574 nM and functioning independently of calcium ions. It effectively inhibits Nigericin-induced inflammasome activation in THP-1 cells and reduces IL-1β release in response to Imiquimod from LPS-primed bone marrow-derived macrophages. This compound is valuable for studying the role of inflammasome activation in various inflammatory diseases and metabolic disorders.
NLRP3-IN-NBC6 is a selective inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 574 nM and functioning independently of calcium ions. It effectively inhibits Nigericin-induced inflammasome activation in THP-1 cells and reduces IL-1β release in response to Imiquimod from LPS-primed bone marrow-derived macrophages. This compound is valuable for studying the role of inflammasome activation in various inflammatory diseases and metabolic disorders.
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