Fig. 1 · Structure
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NLRP3-IN-NBC6
NLRP3 Inflammasome Inhibitor
NLRP3-IN-NBC6 is a selective inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 574 nM and functioning independently of calcium ions. It effectively inhibits Nigericin-induced inflammasome activation in THP-1 cells and reduces IL-1β release in response to Imiquimod from LPS-primed bone marrow-derived macrophages. This compound is valuable for studying the role of inflammasome activation in various inflammatory diseases and metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2068818-02-8 |
| Applications | NLRP3 Inflammasome Inhibitor |
| Formula | C18H16BCl3N2O2 |
| Molecular Weight | 409.50 |
| SMILES | CC(C1=C(N[B-](C2=CC=CC=C2)([O+]=C1N)C3=CC=CC=C3)C(Cl)(Cl)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.