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NNRT-IN-2

NNRTI

NNRT-IN-2 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) that demonstrates broad inhibitory activity against both wild-type and mutant strains of HIV-1. With an EC50 of 22 nM, it effectively inhibits HIV-1 reverse transcriptase. Additionally, NNRT-IN-2 exhibits favorable safety and pharmacokinetic properties, remaining insensitive to CYP and hERG interactions, making it a valuable tool for HIV research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2999794-78-2
Applications	NNRTI
Formula	C₁₉H₁₄F₃N₅O₃
Molecular Weight	417.34
SMILES	CN1C(NN=C1CN2C=CC(C(F)(F)F)=C(C2=O)OC3=C4C=CN=CC4=CC=C3)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.