Fig. 1 · Structure
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NODAGA-NHS
Chelator
NODAGA-NHS is an activated ester of the NODAGA chelator, designed for targeted radiolabeling applications. It facilitates the conjugation of Trastuzumab to form NODAGA-Trastuzumab, enabling the chelation of 64Cu for radiotracer development. This compound is particularly valuable in PET imaging studies of tumors expressing the HER2 receptor, making it a crucial tool in research related to HER2-positive breast cancer and ovarian adenocarcinoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1407166-70-4 |
| Applications | Chelator |
| Formula | C19H28N4O10 |
| Molecular Weight | 472.45 |
| Synonyms | NODA-GA-NHS ester |
| SMILES | OC(C(N(CCN1CC(O)=O)CCN(CC1)CC(O)=O)CCC(ON(C2=O)C(CC2)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.