Fig. 1 · Structure
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Nolpitantium
NK1 Receptor Antagonist
Nolpitantium is a potent and selective competitive antagonist of the tachykinin NK1 receptor. By inhibiting NK1 receptor activation, Nolpitantium effectively blocks the excitability of rat thalamic neurons in response to nociceptive stimulation. This compound is valuable for research into pain mechanisms and the role of neurokinin signaling in various neurophysiological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 153050-21-6 |
| Applications | NK1 Receptor Antagonist |
| Formula | C37H45Cl3N2O2 |
| Molecular Weight | 656.12 |
| Synonyms | SR140333 |
| SMILES | O=C(N1C[C@@](CC[N+]2(CC3)CCC3(C4=CC=CC=C4)CC2)(C5=CC=C(Cl)C(Cl)=C5)CCC1)CC6=CC=CC(OC(C)C)=C6.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.