Fig. 1 · Structure
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Nomifensine maleate
Norepinephrine/Dopamine Reuptake Inhibitor
Nomifensine maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. It effectively inhibits the uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes, showing IC50 values of 6.6 nM, 48 nM, and 830 nM, respectively. This compound exhibits significant antidepressant and analgesic properties, making it valuable in research focused on neurodegenerative diseases, substance addiction, and pain mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 32795-47-4 |
| Applications | Norepinephrine/Dopamine Reuptake Inhibitor |
| Formula | C20H22N2O4 |
| Molecular Weight | 354.40 |
| Synonyms | (±)-Nomifensine maleate; Nomifensin maleate |
| SMILES | NC1=CC=CC2=C1CN(C)CC2C3=CC=CC=C3.O=C(O)/C=C\C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.