(+)-Norfenfluramine is a selective agonist of the 5-HT2B receptor, with a binding affinity (Ki) of 11.2 nM. This compound effectively stimulates the hydrolysis of inositol phosphates, resulting in enhanced intracellular calcium levels. (+)-Norfenfluramine is utilized in research focused on primary pulmonary hypertension and valvular heart disease, providing insight into pathology and potential therapeutic avenues.
(+)-Norfenfluramine is a selective agonist of the 5-HT2B receptor, with a binding affinity (Ki) of 11.2 nM. This compound effectively stimulates the hydrolysis of inositol phosphates, resulting in enhanced intracellular calcium levels. (+)-Norfenfluramine is utilized in research focused on primary pulmonary hypertension and valvular heart disease, providing insight into pathology and potential therapeutic avenues.
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