Fig. 1 · Structure
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Norquetiapine dihydrochloride
Neuroprotective Agent
Norquetiapine dihydrochloride is a neuroprotective agent that functions as a selective HCN1 channel inhibitor with an IC50 of 13.9 μM. It demonstrates selective noradrenaline reuptake inhibition and acts as a partial agonist at 5-HT1A receptors (Ki = 45 nM), while antagonizing presynaptic α2 (Ki = 237 nM), 5-HT2C (Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Additionally, Norquetiapine dihydrochloride exhibits state-dependent blockade of the human cardiac sodium channel Nav1.5 and shows partial anti-inflammatory effects in C57BL/6 mice following LPS injection. This compound is relevant for research into depression and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 111974-74-4 |
| Applications | Neuroprotective Agent |
| Formula | C17H19Cl2N3S |
| Molecular Weight | 368.32 |
| Synonyms | N-Desalkylquetiapine dihydrochloride |
| SMILES | C12=CC=CC=C1N=C(C3=CC=CC=C3S2)N4CCNCC4.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.