Fig. 1 · Structure
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Norquetiapine
Neuroprotective Agent
Norquetiapine, a metabolite of Quetiapine, serves as a neuroprotective agent primarily by selectively inhibiting HCN1 channels with an IC50 of 13.9 μM. It demonstrates noradrenaline reuptake inhibition, partial agonism at the 5-HT1A receptor (Ki = 45 nM), and antagonism at presynaptic α2 (Ki = 237 nM), 5-HT2C (Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Additionally, Norquetiapine exhibits state-dependent blockade of the human cardiac sodium channel Nav1.5 and shows partial anti-inflammatory effects in LPS-injected C57BL/6 mice. This compound can be utilized in research focused on depression and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 5747-48-8 |
| Applications | Neuroprotective Agent |
| Formula | C17H17N3S |
| Molecular Weight | 295.41 |
| Synonyms | N-Desalkylquetiapine |
| SMILES | C12=CC=CC=C1N=C(C3=CC=CC=C3S2)N4CCNCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.