NP3-562 is a potent, orally active inhibitor of NLRP3, a key component of the inflammasome pathway. It effectively suppresses IL-1β release in Nigericin-stimulated THP-1 cells with an IC50 of 66 nM, and in human whole blood with an IC50 of 214 nM. This compound is valuable for investigating the role of NLRP3 activation in inflammatory conditions, particularly in acute peritonitis models.
NP3-562 is a potent, orally active inhibitor of NLRP3, a key component of the inflammasome pathway. It effectively suppresses IL-1β release in Nigericin-stimulated THP-1 cells with an IC50 of 66 nM, and in human whole blood with an IC50 of 214 nM. This compound is valuable for investigating the role of NLRP3 activation in inflammatory conditions, particularly in acute peritonitis models.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
