Fig. 1 · Structure
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NPC 17731
Bradykinin (BK) Receptor Antagonist.
NPC 17731 is a potent bradykinin (BK) receptor antagonist that effectively inhibits both contractile and relaxant responses induced by bradykinin. With an IC50 of 23 nM for contractile effects and 29 nM for relaxant effects, this compound serves as a valuable tool for studying bradykinin signaling pathways. Research applications include investigating cardiovascular responses and potential therapeutic strategies for conditions associated with bradykinin dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 147267-10-5 |
| Applications | Bradykinin (BK) Receptor Antagonist. |
| Formula | C59H95N19O14 |
| Molecular Weight | 1294.50 |
| SMILES | C(=O)(N1[C@@]2([C@](C[C@H]1C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)(CCCC2)[H])[H])[C@@H]3N(C([C@@H](NC([C@H](CC4=CC=CC=C4)NC(CNC(=O)[C@H]5N(C(=O)[C@H]6N(C([C@@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCC6)C[C@H](O)C5)=O)=O)CO)=O)C[C@@H](OCCC)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.