Fig. 1 · Structure
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NPD-2975
Antitrypanosomal Agent
NPD-2975 is an orally active antitrypanosomal agent targeting Human African Trypanosomiasis (HAT). It demonstrates low toxicity in human MRC-5 lung fibroblasts and exhibits efficacy in an acute mouse model of T. b. brucei infection. NPD-2975 shows metabolic stability, with an in vitro IC50 of 70 nM against T. b. brucei. Additionally, it inhibits CYP enzymes, with IC50 values of 0.16 and 0.42 μM for CYP1A2 and CYP2C19, respectively, making it a valuable tool for research in parasitology and drug metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3032452-65-3 |
| Applications | Antitrypanosomal Agent |
| Formula | C14H13FN4O |
| Molecular Weight | 272.28 |
| SMILES | O=C1C(NN=C2C(C)C)=C2N=C(C3=CC=C(F)C=C3)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.