Fig. 1 · Structure
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NPD8790
Mitochondrial Complex I Inhibitor
NPD8790 is a selective inhibitor of mitochondrial respiratory complex I, exhibiting an IC50 of 2.4 µM in Caenorhabditis elegans. This compound demonstrates a high degree of selectivity for nematode mitochondria compared to those of humans, bovines, and mice. NPD8790 serves as an effective anthelmintic agent, targeting and eliminating adult soil-transmitted helminths, making it valuable in parasitology research and the development of new antiparasitic therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 615281-26-0 |
| Applications | Mitochondrial Complex I Inhibitor |
| Formula | C20H24N2 |
| Molecular Weight | 292.42 |
| SMILES | CC(CC1=CC=C(C=C1)C(C2=NC3=C(N2C)C=CC=C3)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.