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NS5A-IN-4

NS5A Inhibitor

NS5A-IN-4 is a potent pan-genotypic inhibitor targeting the NS5A protein of the hepatitis C virus (HCV). It demonstrates exceptional inhibitory activity, with IC50 values of 1.2 pM for genotype 1b, 2,296 pM for genotype 1a, and varying efficacy across genotypes 2a, 3a, 4a, and 5a. Additionally, NS5A-IN-4 features an alkyne group, enabling participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for click chemistry applications. This compound is valuable for research involving HCV infection and drug development strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2088243-03-0
Applications	NS5A Inhibitor
Formula	C₄₇H₄₈N₈O₆
Molecular Weight	820.93
SMILES	COC(N[C@@H](C(C)C)C(N1[C@H](C2=NC=C(C3=CC(C4=CC=CC=C4)=C(C=C3)C#CC#CC5=CN=C([C@H]6N(CCC6)C([C@@H](C7=CC=CC=C7)NC(OC)=O)=O)N5)N2)CCC1)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.