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Form	MW
NS8593 This page	263.34
NS8593 hydrochloride	299.80

NS8593

Name: NS8593
Brand: Adooq Bioscience
SKU: A68189
Availability: OutOfStock

Cat. No. A68189 CAS 875755-39-8

SK channel/TRPM7 Inhibitor

NS8593 is a selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels), specifically targeting the SK1-3 subtypes. It exhibits a reversible inhibition of SK3-mediated currents with Ca2+-dependent potency (Kd values of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+), while leaving intermediate and large conductance K channels unaffected. Additionally, NS8593 inhibits the TRPM7 channel with an IC50 of 1.6 mM. This compound is valuable for research into central nervous system-related diseases and the physiological roles of SK and TRPM7 channels.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	875755-39-8
Applications	SK channel/TRPM7 Inhibitor
Formula	C₁₇H₁₇N₃
Molecular Weight	263.34
SMILES	C1(N[C@@H]2CCCC3=C2C=CC=C3)=NC4=CC=CC=C4N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.