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NSC111552

Catalog No.: A53400
SARS-CoV-2 NSP14 MTase Inhibitor
NSC111552 is a selective inhibitor of the SARS-CoV-2 NSP14 methyltransferase (MTase), demonstrating significant potency. It effectively disrupts FL-NAH binding to the NSP14 MTase with an IC50 value of 5.1 μM. This compound is valuable for research into SARS-CoV-2 replication processes and the development of antiviral therapies targeting the viral MTase activity.
NSC111552 40420-48-2 SARS-CoV-2 NSP14 MTase Inhibitor
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNSC111552 is a selective inhibitor of the SARS-CoV-2 NSP14 methyltransferase (MTase), demonstrating significant potency. It effectively disrupts FL-NAH binding to the NSP14 MTase with an IC50 value of 5.1 μM. This compound is valuable for research into SARS-CoV-2 replication processes and the development of antiviral therapies targeting the viral MTase activity.
Product Information
Catalog NumA53400
FormulaC12H10O3
Molecular Weight202.21
CAS Number40420-48-2
SMILESO=C(C)C1=C(O)C2=C(C=CC=C2)C(O)=C1
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Microbiology > SARS-CoV