Target & Activity
| Target | Activity | Value |
|---|---|---|
| SHP-2 | 318 nM | |
| SHP-1 | 355 nM |
Fig. 1 · Structure
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NSC87877 disodium
SHP inhibitor
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 56932-43-5 |
| Applications | SHP inhibitor |
| Formula | C19H13N3O7S2.2Na |
| Molecular Weight | 503.42 |
| SMILES | C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])C=C2S(=O)(=O)[O-])N=C1.[Na+].[Na+] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 85 mg/mL (168.84 mM) |
| Water | 85 mg/mL (168.84 mM) |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 5 mg/mL
- Vehicle
- 2% DMSO+35% PEG 300+2% Tween 80+ddH2O
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.