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NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.
Targets
| SHP-2 | SHP-1 | |||
| 318 nM | 355 nM |
| In vitro (25°C) | DMSO | 85 mg/mL (168.84 mM) | |
| Water | 85 mg/mL (168.84 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+35% PEG 300+2% Tween 80+ddH2O | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.86 mL | 99.32 mL | 198.64 mL |
| 0.5 mM | 3.97 mL | 19.86 mL | 39.73 mL |
| 1 mM | 1.99 mL | 9.93 mL | 19.86 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.97 mL |
*The above data is based on the productmolecular weight 503.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16120 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 56932-43-5 |
| Formula | C19H13N3O7S2.2Na |
| M. Wt | 503.42 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | NSC-87877, NSC 87877 |
| SMILES | C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])C=C2S(=O)(=O)[O-])N=C1.[Na+].[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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