Catalog No.: A16120

SHP inhibitor


NSC87877 Chemical Structure

CAS NO. 56932-43-5

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.

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Biological Activity

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.
318 nM355 nM
In vitro (25°C) DMSO 85 mg/mL (168.84 mM)
Water 85 mg/mL (168.84 mM)
Ethanol Insoluble
In vivo 2% DMSO+35% PEG 300+2% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.32 mL 198.64 mL
0.5 mM 3.97 mL 19.86 mL 39.73 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16120
Actions Inhibitor
CAS No. 56932-43-5
Formula C19H13N3O7S2.2Na
M. Wt 503.42
Purity >98%
Synonyms NSC-87877, NSC 87877
SMILES C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])C=C2S(=O)(=O)[O-])N=C1.[Na+].[Na+]

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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