Fig. 1 · Structure
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NTPO
DNA damage inducer
NTPO (Nitrilotris methylenephosphonic acid) is a potent DNA damage inducer that effectively induces genomic DNA damage and fragmentation, leading to the activation of ATR-mediated cell cycle checkpoints. Its DNA damaging effects can be mitigated by base excision repair (BER) mechanisms, while remaining unaffected by nucleotide excision repair (NER). This compound is useful for research applications focusing on DNA repair pathways, cellular responses to damage, and the study of cell cycle regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 6419-19-8 |
| Applications | DNA damage inducer |
| Formula | C3H12NO9P3 |
| Molecular Weight | 299.05 |
| Synonyms | Nitrilotris(methylenephosphonic acid) |
| SMILES | OP(CN(CP(O)(O)=O)CP(O)(O)=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.