NUCC-555 is an activin antagonist that targets the Activin A binding pocket, specifically interacting with critical residues such as Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107. This compound effectively inhibits Activin A-mediated activation of hepatic stellate cells (HSCs), promoting liver regeneration and slowing the progression of fibrosis in chronic liver disease models. Additionally, NUCC-555 suppresses ovarian cell proliferation driven by Activin A and reduces follicle-stimulating hormone (FSH) levels in ovariectomized mouse models, making it a valuable tool for research in liver and reproductive health.
NUCC-555 is an activin antagonist that targets the Activin A binding pocket, specifically interacting with critical residues such as Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107. This compound effectively inhibits Activin A-mediated activation of hepatic stellate cells (HSCs), promoting liver regeneration and slowing the progression of fibrosis in chronic liver disease models. Additionally, NUCC-555 suppresses ovarian cell proliferation driven by Activin A and reduces follicle-stimulating hormone (FSH) levels in ovariectomized mouse models, making it a valuable tool for research in liver and reproductive health.
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