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NUCC-555

Name: NUCC-555
Brand: Adooq Bioscience
SKU: A84895
Availability: OutOfStock

Cat. No. A84895 CAS 1060469-90-0

Activin Antagonist

NUCC-555 is an activin antagonist that targets the Activin A binding pocket, specifically interacting with critical residues such as Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107. This compound effectively inhibits Activin A-mediated activation of hepatic stellate cells (HSCs), promoting liver regeneration and slowing the progression of fibrosis in chronic liver disease models. Additionally, NUCC-555 suppresses ovarian cell proliferation driven by Activin A and reduces follicle-stimulating hormone (FSH) levels in ovariectomized mouse models, making it a valuable tool for research in liver and reproductive health.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1060469-90-0
Applications	Activin Antagonist
Formula	C₂₅H₂₅N₅O₃
Molecular Weight	443.50
SMILES	O=C(NCC1=CC=CC=C1)C2=CC(NC(COC)=O)=CC3=C2N(C(C4=CC=CN=C4)=N3)CC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.