Fig. 1 · Structure
Documents & Downloads
NX-1607
Cbl-b Inhibitor
NX-1607 is a potent inhibitor of Cbl-b, an E3 ubiquitin ligase involved in the ubiquitin-proteasome degradation pathway, demonstrating an IC50 value of less than 1 nM. This compound is valuable for cancer research, as Cbl-b plays a critical role in regulating immune responses and has implications in tumor immune evasion. NX-1607 can be utilized in studies aimed at understanding immune modulation and the development of immunotherapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2573775-59-2 |
| Applications | Cbl-b Inhibitor |
| Formula | C30H34F3N5O |
| Molecular Weight | 537.62 |
| Synonyms | Cbl-b-IN-3 |
| SMILES | CN1C([C@@]2(C3=CC(N4CC5=C(C(F)(F)F)C=C(CN6C[C@H](CCC6)C)C=C5C4=O)=CC=C3)C[C@H](C2)C)=NN=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.