Fig. 1 · Structure
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Okadaic acid sodium
PP1/PP2A Inhibitor
Okadaic acid sodium is a potent inhibitor of serine/threonine protein phosphatases, primarily targeting PP2A with an IC50 of 0.1-0.3 nM, and also inhibiting PP1 and PP3 at higher concentrations. This marine toxin promotes the phosphorylation of numerous proteins by blocking phosphatase activity, playing a significant role in cellular signaling pathways. Furthermore, Okadaic acid sodium is implicated in cancer research due to its tumor-promoting properties and its ability to induce tau phosphorylation, making it a valuable reagent for studies on neurodegeneration and cell cycle regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 209266-80-8 |
| Applications | PP1/PP2A Inhibitor |
| Formula | C44H67NaO13 |
| Molecular Weight | 826.98 |
| SMILES | O[C@H](CC[C@@H](C[C@@](C)(O)C(O[Na])=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.