Fig. 1 · Structure
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Okadaic acid
PP1/PP2A Inhibitor
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, with a significantly higher affinity for PP2A (IC50 = 0.1-0.3 nM) compared to PP1 (IC50 = 15-50 nM). Additionally, it inhibits PP3 (IC50 = 3.7-4 nM), PP4 (IC50 = 0.1 nM), and PP5 (IC50 = 3.5 nM), while showing no inhibitory effects on PP2C. This marine-derived toxin is known to increase the phosphorylation of various proteins, playing a role in tumor promotion and inducing tau phosphorylation, making it valuable for studies on phosphatase regulation and neurodegenerative diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 78111-17-8 |
| Applications | PP1/PP2A Inhibitor |
| Formula | C44H68O13 |
| Molecular Weight | 805.00 |
| SMILES | O[C@H](CC[C@@H](C[C@@](C)(O)C(O)=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.