Olaparib-d4-1 is a deuterium-labeled derivative of Olaparib, a potent and orally active inhibitor of poly(ADP-ribose) polymerase (PARP). It exhibits IC50 values of 5 nM and 1 nM for PARP1 and PARP2, respectively, effectively inducing cellular responses associated with DNA repair inhibition. This stable isotope compound is valuable for research applications in cancer therapeutics, particularly in studies involving PARP-mediated pathways and autophagy activation.
Olaparib-d4-1 is a deuterium-labeled derivative of Olaparib, a potent and orally active inhibitor of poly(ADP-ribose) polymerase (PARP). It exhibits IC50 values of 5 nM and 1 nM for PARP1 and PARP2, respectively, effectively inducing cellular responses associated with DNA repair inhibition. This stable isotope compound is valuable for research applications in cancer therapeutics, particularly in studies involving PARP-mediated pathways and autophagy activation.
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