PARP1

Cat. No.

A12750

CAS No.

1048371-03-4

UPF 1069

UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

Cat. No.

A15873

CAS No.

1645286-75-4

AZ6102

AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.

Cat. No.

A21356

CAS No.

912445-05-7

Veliparib dihydrochloride

Synonyms: ABT-888

Veliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively.

Cat. No.

A28978

CAS No.

93117-07-8

5-AIQ hydrochloride

Synonyms: 5-Aminoisoquinolin-1-one hydrochloride

5-AIQ hydrochloride is a selective inhibitor of PARP-1, an important enzyme involved in DNA repair. This compound exhibits protective effects against ischemia-reperfusion injury in liver tissue, making it a valuable tool for studying conditions related to hepatic ischemia-reperfusion. Its applications extend to research focused on oxidative stress and cell survival mechanisms, providing insights into potential therapeutic strategies for liver protection.

Cat. No.

A28984

CAS No.

1015-89-0

6(5H)-Phenanthridinone

6(5H)-Phenanthridinone is a potent inhibitor of PARP-1, a key enzyme involved in DNA repair processes. This compound exhibits significant immunomodulatory effects and has been shown to inhibit cell proliferation. It is employed in cancer research to explore therapeutic strategies targeting DNA repair pathways and to enhance the efficacy of chemotherapeutic agents.

Cat. No.

A29125

CAS No.

420849-22-5

TIQ-A

TIQ-A is a potent inhibitor of TNKS2 (tankyrase 2), exhibiting an IC50 of 24 nM. This compound has shown promise as an anti-ischemic agent, potentially modulating pathways involved in ischemic injury. It serves as a valuable tool for research focused on cellular stress responses and the role of TNKS2 in various diseases.

Cat. No.

A10994

CAS No.

284028-89-3

XAV 939

XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).

Cat. No.

A14182

CAS No.

283173-50-2

Rucaparib

Synonyms: AG-014699; PF-01367338

Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.

Cat. No.

A15215

CAS No.

344458-19-1

PJ34

PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.

Cat. No.

A12665

CAS No.

344458-15-7

PJ 34 hydrochloride

Synonyms: PJ34

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).

Cat. No.

A10111

CAS No.

763113-22-0

Olaparib (AZD2281)

Synonyms: KU-0059436; AZD2281

Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.