Fig. 1 · Structure
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Olodanrigan sodium
AT2R Antagonist
Olodanrigan sodium is a selective, orally active antagonist of the angiotensin II type 2 receptor (AT2R). This compound demonstrates significant analgesic activity, particularly in the context of neuropathic pain. Its mechanism involves the inhibition of augmented AngII/AT2R-mediated activation of p38 and p42/p44 MAPK pathways, which contributes to the reduction of dorsal root ganglion (DRG) neuron hyperexcitability and sprouting. Olodanrigan sodium is being explored for therapeutic applications in managing neuropathic pain.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1316755-17-5 |
| Applications | AT2R Antagonist |
| Formula | C32H28NNaO5 |
| Molecular Weight | 529.56 |
| Synonyms | EMA401 sodium; PD-126055 sodium |
| SMILES | O=C([C@H]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O[Na] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.