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Form	MW
rac-Olodanrigan This page	507.58
Olodanrigan	507.58
Olodanrigan sodium	529.56

rac-Olodanrigan

AT2R Antagonist

rac-Olodanrigan is a potent and selective antagonist of the angiotensin II type 2 receptor (AT2R). With IC50 values of 75.2 nM for AT2R and 2918 nM for AT1R, it demonstrates high specificity for its target. This compound effectively induces dose-dependent relief of mechanical allodynia in rat models with chronic constriction injury (CCI) of the sciatic nerve, making it a valuable tool for research in pain pathways and potential therapeutic applications in neuropathic pain.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	152362-51-1
Applications	AT2R Antagonist
Formula	C₃₂H₂₉NO₅
Molecular Weight	507.58
Synonyms	rac-EMA401; rac-PD-126055; EMA400
SMILES	O=C(C1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.