ON 146040

Catalog No.: A16266

dual PI3K and BCR-ABL inhibitor

ON 146040 Chemical Structure

CAS NO. 1404231-34-0

ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $320.00

Special Price $256.00

10 mg

Regular Price: $480.00

Special Price $384.00

50 mg

Regular Price: $1,400.00

Special Price $1,120.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.43 mL 102.13 mL 204.27 mL
0.5 mM 4.09 mL 20.43 mL 40.85 mL
1 mM 2.04 mL 10.21 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

*The above data is based on the productmolecular weight 489.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16266
Actions Inhibitor
M. Wt 489.55
Formula C24H23N7O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1404231-34-0
Synonyms ON-146040, ON146040
SMILES O=C(NC(C=NC(NC1=CC=C(N2CCN(C)CC2)C=C1)=N3)=C3S/4)C4=C\C5=CC=C([N+]([O-])=O)C=C5

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