ON 146040

Catalog No.: A16266
dual PI3K and BCR-ABL inhibitor
ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM.
Grouped product items
Size Price Stock Qty
5mg
$280.00
In stock
10mg
$450.00
In stock
50mg
$1,400.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM.
Targets
Target Value
Product Information
Catalog Num A16266
Formula C24H23N7O3S
Molecular Weight 489.55
CAS Number 1404231-34-0
SMILES O=C(NC(C=NC(NC1=CC=C(N2CCN(C)CC2)C=C1)=N3)=C3S/4)C4=C\C5=CC=C([N+]([O-])=O)C=C5
Synonyms ON-146040, ON146040
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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