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ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.43 mL | 102.13 mL | 204.27 mL |
| 0.5 mM | 4.09 mL | 20.43 mL | 40.85 mL |
| 1 mM | 2.04 mL | 10.21 mL | 20.43 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
*The above data is based on the productmolecular weight 489.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16266 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 489.55 |
| Formula | C24H23N7O3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1404231-34-0 |
| Synonyms | ON-146040, ON146040 |
| SMILES | O=C(NC(C=NC(NC1=CC=C(N2CCN(C)CC2)C=C1)=N3)=C3S/4)C4=C\C5=CC=C([N+]([O-])=O)C=C5 |
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