Fig. 1 · Structure
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Oncrasin-72
DNA/RNA Synthesi
Oncrasin-72 (NSC-743380) functions as an RNA polymerase II inhibitor, demonstrating significant antitumor activity by inducing cell death and inhibiting growth in various human cancer cell lines. Its mechanism involves the activation of JNK and the inhibition of STAT3 pathways. This reagent is essential for studies focused on DNA/RNA synthesis and for assessing pharmacokinetics in biological samples, as validated analytical methods have successfully quantified Oncrasin-72 concentrations in rat plasma across multiple dosage groups.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 92407-90-4 |
| Applications | DNA/RNA Synthesi |
| Formula | C16H14ClNO |
| Molecular Weight | 271.74 |
| Synonyms | NSC-743380 |
| SMILES | ClC1=CC=CC(CN2C=C(CO)C3=C2C=CC=C3)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.