Fig. 1 · Structure
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ONO-2952
TSPO Antagonist
ONO-2952 is a potent and selective antagonist of the translocator protein (TSPO), with inhibition constants (Ki) ranging from 0.33 to 9.30 nM for both rat and human TSPO. This compound demonstrates remarkable selectivity for TSPO over a variety of other receptors, transporters, ion channels, and enzymes. ONO-2952 alleviates stress by modulating the activation of the noradrenergic system in the brain, without inducing amnesic effects. It holds promise for therapeutic applications in treating irritable bowel syndrome and related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 895169-20-7 |
| Applications | TSPO Antagonist |
| Formula | C22H20ClFN2O2 |
| Molecular Weight | 398.86 |
| SMILES | CC(N([C@H]1C2=CC=C(Cl)C=C2OC)CC3(C4=C1NC5=C4C(F)=CC=C5)CC3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.