Fig. 1 · Structure
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ONO-8430506
Autotaxin /ENPP2 Inhibitor
ONO-8430506 is a potent and orally bioavailable inhibitor of autotaxin (ATX), also known as ENPP2, exhibiting an IC90 of 100 nM for ATX activity in mouse plasma. Through its inhibitory action on ATX, this compound plays a crucial role in modulating lysophosphatidic acid (LPA) signaling pathways. ONO-8430506 is useful for studies investigating the biological functions of ATX in diseases such as cancer and fibrosis, making it a valuable tool for research applications aimed at targeting the LPA signaling axis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1354805-08-5 |
| Applications | Autotaxin /ENPP2 Inhibitor |
| Formula | C27H28FN3O3 |
| Molecular Weight | 461.53 |
| SMILES | O=C(C12CCC(CC1)(C2)CC(N3CC4=C(CC3)C5=C(N4CC6=CC=C(C=C6)F)N=CC=C5)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.