Fig. 1 · Structure
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ONO-AE 248
Prostaglandin Receptor Agonist
ONO-AE 248 is a selective agonist of the EP3 prostaglandin receptor, exhibiting notable cardioprotective properties. It significantly reduces myocardial infarction size by specifically targeting the EP3α receptor in murine models, with its beneficial effects occurring independently of hemodynamic changes. The protective mechanism may involve the activation of protein kinase C and the opening of K(ATP) channels, highlighting its potential utility in cardiovascular research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 211230-67-0 |
| Applications | Prostaglandin Receptor Agonist |
| Formula | C22H36O5 |
| Molecular Weight | 380.52 |
| SMILES | CCCCC[C@H](OC)/C=C/[C@@H]1[C@H](C(C[C@H]1OC)=O)C/C=C\CCCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.